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Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours

Clinicaltrials.gov ID

NCT05489211

Status

Recruiting

Study Type

Interventional, Phase 2

Sponsor

AstraZeneca

Start Date

Anticipated End Date

Study Contact

Name: AstraZeneca Clinical Study Information Center

Phone Number:1-877-240-9479

Email: information.center@astrazeneca.com

About the Study

TROPION-PanTumor03 will investigate the safety, tolerability, and anti-tumour activity of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours.

Conditions

  • Endometrial Cancer

  • Gastric Cancer

  • Metastatic Castration-resistant Prostate Cancer

  • Ovarian Cancer

  • Colorectal Cancer

  • Urothelial Cancer

  • Biliary Tract Cancer

Inclusion/Exclusion Criteria?

Primary, Secondary, Other Outcome Measures??

Locations in Canada

  • Sunnybrook Hospital, Toronto, Ontario, M4N 3M5, Canada

  • Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada

  • CHUM, Montreal, Quebec, H2X 0A9, Canada

  • McGill University Health Centre, Montreal, Quebec, H4A 3J1, Canada

  • Hôpital Enfant-Jésus, Quebec, Quebec, G1J 1Z4, Canada

Apply Now

About the Study

TROPION-PanTumor03 will investigate the safety, tolerability, and anti-tumour activity of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours.

Conditions

  • Endometrial Cancer

  • Gastric Cancer

  • Metastatic Castration-resistant Prostate Cancer

  • Ovarian Cancer

  • Colorectal Cancer

  • Urothelial Cancer

  • Biliary Tract Cancer

Interventions

DRUG:

  • Datopotamab deruxtecan (Dato-DXd)

  • AZD5305

  • Durvalumab

  • Capecitabine

  • 5-Fluorouracil

  • Volrustomig

  • Carboplatin

  • Leucovorin LV

  • Bevacizumab

  • Rilvegostomig

  • Prednisone/ prednisolone

Locations in Canada

  • Sunnybrook Hospital, Toronto, Ontario, M4N 3M5, Canada

  • Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada

  • CHUM, Montreal, Quebec, H2X 0A9, Canada

  • McGill University Health Centre, Montreal, Quebec, H4A 3J1, Canada

  • Hôpital Enfant-Jésus, Quebec, Quebec, G1J 1Z4, Canada

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